Synthesis of aspirin lab report discussion pdf. Turn on the aspirator and transfer the aspirin slurry into the funnel. In the reaction the hydroxyl group on the benzene ring in salicylic acid reacted with acetic anhydride to form an ester functional group. [1] The document describes an experiment to analyze the purity of aspirin through acid-base titration and back-titration. The synthetic scheme for aspirin is indicated above. Suggestions for improving yield and purity are discussed along with end-of-report questions on differentiating products using NMR. 081g of Salicylic acid was obtained after the first synthesis. More recently, studies have indicated that daily intake of small doses of aspirin can lower the risk of heart attack and stroke in high-risk patients. 2009 •. The procedures used to accomplish these tasks in this experiment will be (1) vacuum filtration and (2) recrystallization. To do this, set up a ring stand with a clamp. Chem 2540 SP17 Callam/Paul SYNTHESIS OF ASPIRIN DIGITAL LABORATORY REPORT PREPARED BY: LAB ROOM: DATE: TA: Johnny A DISCUSSION SECTION IS Question: EXPERIMENT 10 - SYNTHESIS OF ASPIRIN OBJECTIVE You will become familiar with the synthesis of aspirin, also known as acetylsalicylic acid. For Synthesis of Aspirin Lab Report - Free download as Word Doc (. 447 chem (Lab). Full Report Part - Free download as Word Doc (. In this experiment, aspirin was produced using this same method. Used as a pain reliver, Salicin, has been extracted from the bark of willow and poplar trees for hundreds of years. Dominique Linkins Kevin Cheah Organic II Lab 2 November 2020 Aspirin Lab Report Introduction Aspirin is one of the world’s oldest drugs and it can be traced back to ancient Greece and Rome. Then, add 0. Awais Ihsan. Recrystallization of aspirin. The mechanism for this synthesis provides examples of three major classes of chemical reactions: hydrolysis In this lab experiment, acetylsalicylic acid will be produced from acetic acid and salicylic acid with sulphuric acid as a catalyst. This was a white powder and had a melting point range of 134-135 degrees Celsius. Download Free PDF. Here it is hydrolyzed to form the acetate and salicylate ion. Dr. The mechanism for this synthesis provides examples of three major classes of chemical reactions: hydrolysis, condensation, and proton transfer. Connect the other end of the rubber tubing to an aspirator in the lab. organic chemistry experiment. doc / . Date: 10/09/2020 Experiment 006: Synthesis of Aspirin References: 1. Synthesis of Aspirin Lab Report. Synthetic of Aspirin-lab Adowa Walo Clark Atlanta University, USA February 2020 Analgesics are for This study details the synthesis of aspirin through acetylation of salicylic acid. 11-10-20. Aspirin is an effective analgesic (pain reliever), antipyretic (fever reducer) and anti-inflammatory agent and is one of the most widely used non-prescription drugs. TLC analysis Synthesis of aspirin lab report Omar Ashraf Kamaleld's Ahmed Elsayed Elfar Practical 2: PREPARE A SOLID ORGANIC COMPOUND Introduction Aspirin is one of the most affordable but safe painkillers available on today's market, with about 35,000 tons of consumption annually. Heat the resulting turbid solution / oily liquid until the Experiment 8 – Synthesis of Aspirin. If no crystals form, gently scratch the sides of the flask with the stirring rod. Jan 8, 2012 · Collect the aspirin crystals by vacuum filtration. Clamp a side-arm flask to the ring stand, and connect a piece of rubber tubing to the side-arm. Transcribed image text: EXPERIMENT 10 - SYNTHESIS OF ASPIRIN OBJECTIVE You will become familiar with the synthesis of aspirin, also known as acetylsalicylic acid. 225 Lab Report Guidelines–The two-step synthesis of Aspirin fall 2023 f The use of words “I” and “We” are prohibited. Store the recovered crystals in your drawer until the next lab period to give the crystals time to dry completely before the new melting point is taken. 600g of aspirin was obtained after the second synthesis. Also, to evaluate the product by reaction with iron (III) chloride. Using a clean stirring rod, place a crystal of salicylic acid into the first test tube. The crude aspirin was purified through recrystallization with ethanol Jan 1, 2024 · Its synthesis, which is a fundamental process in pharmaceutical chemistry, involves the acetylation of salicylic acid. 2 mL of 8% hydrazine was added to the test tube with the 3-nitrophtalic acid. What reaction would cause this to happen? 13. docx), PDF File (. To understand this, an experiment was conducted – synthesis of Aspirin. Safety Precautions: All of the materials in this experiment are relatively harmless. The experimental procedure, data and calculations, NMR analysis, and discussion on potential impurities and yield are highlighted. Date of Experiment 03/29/ Introduction. Determination of the purity of aspirin samples by TLC Four test samples, namely recrystallized aspirin, crude aspirin, aspirin obtained from the pharmacy, and 2-hydroxy-benzoic acid, were dissolved in ethanol. Transfer the filter paper and aspirin to a pre-weighed watch glass and Example: alcohols react with anhydrides and acid chlorides (Weldegirma, 2013). 157/138 x 4= 5 5) You would use hot water, because if it was room temperature it would dissolve. pdf from CHM 25501 at Purdue University. Synthesis Of Aspirin Lab Report National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Guidelines for the Use of Animals in Neuroscience and Behavioral Research Laboratory Manual for Organic Chemistry Kenneth F. Scratch the bottom of the beaker with a stirring rod. Acetylsalicylic acid commonly known as aspirin is the most widely used drug in the world today. In this experiment aspirin, also known as acetylsalicylic acid, was synthesized from salicylic acid and acetic anhydride. Aspirin that has been stored for a long time may give a vinegar-like odor and give a purple color with FeCl3. pdf from CPHY CPHY-112L at Clark Atlanta University. 928 g with a mp of 130-134oC . The crude aspirin product was purified through Conclusion: The purpose of this experiment, the Synthesis of Aspirin, is to synthesize aspirin the same way performed by manufacturers. Synthesis of Aspirin. Put it into a dry pear shaped flask and add 2 cm 3 of ethanoic anhydride followed by 8 drops of concentrated phosphoric acid. This mixture is heated over a hot plate until the solid is dissolved. The forth test tube is the control. Add about 1 mL of deionized water to five clean 10-cm test tubes. Wash the crystals with 5 mL of the cold DI water. The laboratory synthesis of a compound usually requires the product to go through a series of steps to isolate it from the reaction mixture and any soluble impurities. Aspirin alters the oxygenase activity of prostaglandin synthetase by moving the acetyl group to a terminal amine group 4. What steps could you take to improve the yield of aspirin in this particular experiment? The objective of this experiment is to enable us to conduct the synthesis of aspirin, reinforce the skills of recrystallisation and reinforce the technique of melting point determination. The purpose of this lab is to prepare acetylsalicylic acid by esterification of salicylic acid. In this experiment you will be synthesising and purifying two common analgesics (painkillers), week 1 : acetaminophen and week 2 : aspirin (i. To confirm if the product obtained was acetylsalicylic acid (aspirin), the melting point was obtained and compared with the literature value of aspirin’s melting point. Preparation of Aspirin. Aspirin obtained in lab should not be ingested. Crystals of aspirin should form. DISCUSSION Aspirin is a widely used analgesic (pain reducer), anti-inflammatory, and View Synthesis of a Virtual Sample of aspirin Lab Report. Suzanne Slayden, 2018, Chemistry 213, 214, 272 Laboratory Experiments, 7 th Edition, pages 42 – 50. 87). Its analgesic, antipyretic, and anti-inflammatory properties make it a powerful and effective drug to relive symptoms of pain Wash the crystals in the funnel with two 3-mL portions of ice-cold water. The goal of this lab was met as the limiting reagent was identified as salicylic acid and the presence of this substance was shown by the result of its reaction with FeCl3, the color purple. Organic synthesis is a process of converting a starting material to a certain product through various reactions and observations. To determine actual yield of acetylsalicylic acid isolated. In a fume cupboard, warm the mixture in a hot water bath, with swirling, until all the solid has Jun 4, 2019 · Experimental Procedure. The amount of crude aspirin synthesized was 3. Synthesis of Aspirin, Distance Learning Fall 2020, accessed via Keep crystals of aspirin inside flask until dry 17. Aspirin was synthesized from salicylic acid and acetic anhydride using phosphoric acid as a catalyst. Aspirin - Lab Report - Free download as Word Doc (. Add 5 ml of water with a pen drop of aspirin product in second test tube 20. A preweighed sample of 1 gram of 3-nitrophtalic acid in a 20x150 test tube. Salicylic acid was reacted with acetic anhydride to produce 3. Cool the mixture by placing the flask in an ice bath for 10 minutes. pdf from CHEM 262 at University of North Carolina, Chapel Hill. Place the remaining crude product into a clean 125 mL Erlenmeyer flask. Acetylsalicylic acid (ASA), which is being sold under the trade name "aspirin" by the Bayer Company is synthesized by the conversion of Salicylic acid (SA As in many organic reactions, the synthesis in this experiment is an equilibrium reaction. Discussion. It was thin, short white crystals and had a melting point range or 154-155 degrees Celsius. It has analgesics, antipyretic and anti-inflammatory Conclusion The purpose of this laboratory was to create the synthesis of an aspirin and oil of wintergreen as well as a qualitative test to judge the purity of the aspirin previously prepared. 5. You will crystallize the product and calculate theoretical and percentage yields for the product. The experiment described here differs from these typical syn-theses in three respects. And on the other hand, the percentage yield was calculated for the same aspirin and several fragrant esters were prepared. It is carried out to form ester from an acid and an alcohol. Stir occasionally to keep mixture in the reactive state. In the second, place a crystal of powdered commercial aspirin, and in the third, place a crystal of your synthesized aspirin. Procedure. 1 Excerpt. Once most or all is dissolved, add 40 mL water. 3 mL acetic anhydride. 529 grams of salicylic acid on a balance and placng it into a 50 mL Erlenmeyer flask. The ability of aspirin to diminish inflammation is due to its inhibition of the synthesis of prostaglandins. Introduction: E. Allow 5 minutes for the aspirin to crystallize from the solution. Aspirin passes through the acidic stomach contents ad does not ionize and form the salicylate ion until it reaches the alkaline conditions in the intestines. The use of aspirin had its origin in the 18 th century, when it was found that an extract from the bark of willow trees was useful in The purpose of the experiment is to synthesize, isolate, and purify 2-acetoxybenzoic acid and. 4g of salicylic acid is measured in a 100ml conical flask and is recorded. In this laboratory activity, aspirin is aimed at being synthesized using The one-step synthesis of aspirin from salicylic acid is described in many general chemistry laboratory manuals (8) and may be traced to a report by Brown and Friedman (6 ). Students synthesise aspirin and evaluate the purity of their product using 1H-NMR spectroscopy. 027M 2) Not a question 3) Overall the reaction is the conversion of oil of wintergreen to the salicylic acid. to touch the white surface with your fingers. Oct 6, 2023 · 1AS 030. Discussion that could have occurred is that the sample was not allowed enough time to dry fully in the Buchner filtration system. This laboratory introduces students to aspects of practical organic chemistry including synthesis, crystallization, stoichiometry, and percent yield. 3 to 4 drops of conc. Upon addition of cold water, acetic acid was removed as a byproduct and aspirin precipitated out. DISCUSSION Aspirin is a widely used analgesic (pain reducer), anti-inflammatory, and antipyretic (fever reducer) View Lab - Synthesis of Aspirin-lab report. View Lab - Synthesis and Analysis of Aspirin Lab Report. An experiment is described that is suitable for the early portion of the laboratory in a general chemistry course and integrates organic examples. Fealy. Download synthesis of aspirin lab report and more Chemistry Schemes and Mind Maps in PDF only on Docsity! Aspirin synthesis from salicylic acid. It provides background on aspirin including its discovery and composition. View Lab - Lab Report - Exp 1. Set test tubes; 5 mL of water with a pen drop of salicylic acid in first test tube 19. 6mL of acetic anhydride is added to the salicylic acid to the flask in the fumehood. 1. View Lab - aspirin from CHEM 2540 at Ohio State University. pdf from [Laboratory 11_ Determining the Purity of Aspirin by Titration] - Determining the Purity of Aspirin View exp 1 xhem 262 lap report. Sulphuric acid is added to the mixture and is swirled. Nov 18, 2013 · Results. Run the vacuum for ten minutes. known synthesis of aspirin, which is often part of the traditional organic chemistry curriculum. Mix gently and take TLC of reactant. txt) or read online for free. LAB REPORT – EXPERIMENT 9 SYNTHESIS OF ASPIRIN. To understand the chemistry Advanced Organic Chemistry. It is employed as an analgesic (pain relief), an anti-pyretic (fever control) and an anti-inflammatory. In this reaction, an acetyl group is introduced into a chemical compound. Salicylic acid was reacted with acetic anhydride to produce aspirin and acetic acid. The TLC plate which was spotted with each test sample was let to dry. 1 therefore students must determine the purity of their product. Karla Gonzales CHEM 3220 Synthesis of Aspirin Summary: In this experiment, we are synthesizing aspirin reacting salicylic acid with acetic anhydride and using phosphoric acid as the acid catalyst. BUS 4402 DISCUSSION ASSIGMENT 5. To prepare acetylsalicylic acid from salicylic acid and acetic anhydride. Abstract: The goal of this experiment was to synthesize aspirin. Analysis of Aspirin Lab Report - Free download as PDF File (. Aspirin-Synthesis-Lab-Report. e. In the meantime, put a wash bottle filled with distilled water in ice water to cool. Mixture is heated for 10 to 15 min to complete reactions. Katz,2017-07-20 Preparation of Aspirin. Standard SYNTHESIS OF ASPIRIN LAB REPORT 3 Introduction The type of reaction formed in this experiment was an acetylation reaction, which is an esterification reaction with acetic acid. Though aspirin has numerous benefits, there are several adverse affects as well. docx. Chemistry lab report University of Missouri–St. - The document describes an experiment to synthesize aspirin through esterification of salicylic acid and acetic anhydride. It then details the procedure for preparing aspirin through the reaction of salicylic acid with acetic anhydride, followed by purification through recrystallization. Crude Product Reagent Salicylic acid Molecular Weight Grams Moles 42. Furthermore, in the second part of this lab experiment, the synthesized aspirin will be recrystallized in water and the melting point of it will be compared to the crude aspirin 1. High concentrations of acetylsalicylic acid (ASA) or aspirin can cause harm to the body, so aspirin also has to be diluted to become a helpful rather than a harmful drug. R: Synthesis of Aspirin (Report) is shared under a not declared license and was authored, remixed, and/or curated by LibreTexts. George Mason University, Department of Chemistry and Biochemistry. Put a condenser on the flask. Furthermore, since you are writingthis as a journal paper would be written;avoid phrases such as“in this experiment” or“this is animportant reaction to practicing organic chemists. and the amount of pure aspirin synthesized was 2. If lots of solid remains, add more ethanol in 1-mL portions. This resulted in creating crystals and used to filter in the Hirsh funnel. The product was recrystallized and had a Jul 28, 2022 · This automated setup performed the well-. Add a minimum amount of hot acetyl acetate into the flask and gently heat the mixture on a steam bath. Biomedical Chromatography. Oct 15, 2020 · Since its first synthesis in 1897, several medicinal roles and mechanisms of action of Aspirin have become apparent, the latest among these being its role in cancer prevention and treatment Procedure. 029 grams. Post Lab Questions- Aspirin I 1) 4 x 1/152= . 2 The salicylate ion forms the therapeutic part of the aspirin. Exposing students to simple. Synthesis of Aspirin Data and calculations: The crude product weighed 0. The main procedures are preparation of aspirin, recrystallisation of aspirin and lastly determining the melting point of the aspirin. docx from CHEM 262L at University of North Carolina, Chapel Hill. laboratory automation is an The amount of products formed in a chemical reaction is determined by the limiting reagent. The alcohol on salicylic acid attacks the carbonyl group on acetic anhydride, then the compound is deprotonated. 169. Aspirin is a known pain reliever, anti-inflammatory, and a fever reducer that is derieved from acetylsalicylic acid. Aspirin can be synthesized under acidic or basic conditions using acetyl chloride or acetic anhydride in the presence of salicylic acid” [15, 27, 28]. Oct 1, 1998 · PDF. ii. Post lab 11 - Green Synthesis of a Fluorescent Natural Product; Week 7 biodiesel synthesis experiment; Synthesis of Aspirin Pre-Lab Report USF; Pre-Lab Green - Orgo lab; CH 20 HW - Answer and breakdown to CH 20 Homework; Post Lab 8 multi step Stage one. ”. Hosmane,2017-04-27 Advanced Inorganic Chemistry: Applications in Everyday Life connects key topics on the subject with actual experiences in nature and everyday life. determine if pure aspirin was synthesized. 3. Aspirin Synthesis Lab Report By: Meghan Tillger Chem 221-Dr. Section 2: Safety Precautions and Waste Disposal . Experiment 8: Preparation of Aspirin Lab Partner: Ileana Professor Chadegani CHM 100 - 60 Martha L. 5 mL syringe, my partner, Kelsey, added one mL of acetic anhydride to the flask. practice the art of chemical synthesis) and to apply the previously learned techniques of recrystallisation, and melting point determination to confirm the synthesis and assess purity. The objective of this experiment is to enable us to conduct the synthesis of aspirin, reinforce the skills of recrystallisation and reinforce the technique of melting point determination. Analgesics are compounds used to reduce pain, antipyretics are compounds used to reduce fever. *FOR REFERENCE USE ONLY, DO NOT COPY FROM THIS DOCUMENT* Professor: Gita Venkatakrishnan synthesis of aspirin abstract the purpose of conducting this experiment Analytical determination and pharmacokinetics of robenacoxib in the dog. Add ethanol (about 1 mL for every gram of crude product) and warm in the water bath at about 50°C. The student conducted an experiment to synthesize aspirin. This particular chemical test takes advantage of one of the differences between salicylic acid and aspirin, namely the functional group called phenol. Brief history and technique overview. pdf from CHEM 101 at Walter Payton College Prep. Purity of the aspirin. edu10002-assignment-1b learning activity plan An esterification reaction was performed to convert salicylic acid to acetylsalicylic acid (aspirin). Place your remaining crude aspirin in a large test tube and stir with a minimum volume (this will vary depending on your crude yield but it is typically about 2-3 mL per gram of crude product) of hot ethanol (use a steam bath) . pdf), Text File (. You will need cold water in the filtration step to follow. In this lab, we will be using a chemical test to de-termine the purity of the aspirin you synthesized. When the reaction is complete, add 50 mL of cold water to the reaction mixture. 169 grams of pure aspirin. Put a Büchner funnel with a rubber stopper in the flask. Press lightly with the pencil so as not to damage the silica layer. Pour the mixture into a vacuum filtration and rinse the flask with water. Using a 2. Cerny,Christopher E. It is the two-step synthesis of aspirin starting from oil of wintergreen. analyze salicylic acid, crude product, and acetylsalicylic acid via Thin-Layer Chromatography to. Let it cool to room temperature. Add about 1 mL of deionized water to five clean 10cm test tubes. 029 grams of crude aspirin, which was further purified to yield 2. Synthesis of Aspirin Lab; 2020. Synthesis of 13Cor 14C-labeled Aspirin has also facilitated the real-time analysis of acetylation of ubiquitin [15, 29], hemoglobin [15, 30], and human serum albumin [15, 27]. Weigh aspirin in filter on electronic scale 18. Sodium hydroxide solutions are corrosive. The purpose was to synthesize and purify aspirin and analyze the reactants and products using thin-layer chromatography. The document describes a chemistry investigatory project on the preparation of aspirin. Stir with a stirring rod. The goal of this experiment was to synthesize aspirin. An esterification reaction was performed to convert salicylic acid to acetylsalicylic acid (aspirin). Aspirin Synthesis Formal Lab Report Introduction The first goal of this laboratory was to explore different ways in which aspirin could be synthesized to achieve the highest yield and the greenest, most economical synthesis. Salicylic acid was reacted with acetic anhydride in the presence of sulfuric acid to produce aspirin. Find the mass of the purified aspirin. Experiment 4: Preparation of Acetylsalicylic Acid (Aspirin) Objectives i. Chemistry- Asprin Synthesis Lab Report - Free download as Word Doc (. Place the flask in an ice bath and stir the mixture. doc), PDF File (. Rapid and sensitive determination of acetylsalicylic acid and salicylic acid in plasma using liquid chromatography-tandem mass spectrometry: application to pharmacokinetic study. Alexa Caras, Section 0906, 11/16 & 11/30, lab partner: Savannah Meyer, Synthesis of Aspirin b. Add 5 mL of filtrate from flask into third test tube 21. 2. This type of reaction is one of the most important in organic synthesis due to the significance of its products These reactions simply result in the production of an ester, but these esters are useful in many different aspects of life Esterification reactions happen in other places outside of research labs, they are prevalent in several Aspirin is one of the most widely used medications in the world. Add 10 mL water to the ethanol / aspirin solution. In step 5 it states to allow 5 minutes for the aspirin to crystallize, but the sample in laboratory only crystallized for about 3 minutes (French et al. LAB REPORT EXPERIMENT 21 Synthesis of Aspirin (Acetylsalicylic Acid) 1. One popular drug that does both is aspirin. The melting point of the product obtained from the experiment was found to be 130 C, this falls well within the range of the literature value of aspirin’s melting point Be as specific as possible. Introduction The Introduction is written in Present Tense. We began by weighing out 0. pdf - Free download as PDF File (. Take about 1 g of your sample of 2-hydroxybenzoic acid and weigh it accurately. Louis; Chemistry) 1: Synthesis of Aspirin (Experiment) is shared under a license and was authored, remixed, and/or curated by LibreTexts. Salicylic acid reacts with acetic anhydride in the presence of sulfuric acid to form aspirin. Using the mixture of salicylic acid, acetic anhydride, and some deionized water. Place the plates on a clean dry surface and using a pencil and a ruler draw a line 2. Differing from other Synthesis of Aspirin: Procedure:Synthesis of Luminol: 1. Ayala Abstract The purpose of the experiment was to prepare aspirin from salicylic acid and acetic anhydride. Kristoffer Balintona 23 February, 2018 AP Chemistry Periods 2/6 Synthesis and Analysis of The purpose of this experiment was to synthesize aspirin by reacting salicylic acid and acetic anhydride in the presence of phosphoric acid to form acetylsalicylic Acid. C8H803+2OH+2H30+ +(CH3CO)2O 3H20+ CH3COOH+ Aspirin 4) 180. Mechanism of synthesizing Aspirin Experimental Section Add 138 mL of salicylic acid, a boiling stone, and one drop of 85% phosphoric acid to a conical vial. . PROCEDURE: This experiment was completed over the course of two lab periods to allow for proper synthesis and recrystallization of the acetylsalicylic acid. Fall 2020. The uses of aspirin are summarized, including for relieving pain Synthesis Of Aspirin Lab Report Pdf Karsten Schrör Advanced Inorganic Chemistry Narayan S. View PDF. 1 Abstract The purpose of this lab is to synthesize aspirin from the mixture of acetic anhydride and salicylic acid. Creating a vacuum when pouring the liquid will allow the solid to be trapped when the liquid gets drained. 0 cm from the short edge. To let dry for a week and weigh the product and determine the actual yield of crystalized aspirin. a. Part I Synthesis 1 Download synthesis of aspirin lab report and more Chemistry Schemes and Mind Maps in PDF only on Docsity! May 2, 2024 · Laboratory experiment describing the synthesis of aspirin (acetylsalicylic acid) from salicylic acid and acetic anhydride. View Synthesis of Aspirin Lab Manual. 5 Acetic anhydride The yield limiting reagent is Theoretical yield of aspirin: mol Actual yield: Percentage yield organic chemistry experiment. (After lab) Using the calibration curve to calculate the amount of aspirin in one tablet or pill. Collect two TLC plates of dimensions 10 cm × 5 cm. Synthesis of Aspirin: Acetylation of Salicylic Acid O O HO O O H O OH 1 . Add 15 mL of water and cool the 100 mL beaker in a larger beaker with ice water. if np pk gb ns tf fv ix lp dk