Tianeptine sulfate dosage reddit.

Tianeptine sulfate dosage reddit S. I was curious about the ethyl ester sulfate because it supposedly lasts longer than sulfate and potentially is more potent, but I’m not sure. There are much better ways to achieve the same effects, without the risks. Just a few rough days here and there. Tianeptine is addictive and it can sneak up on you. While primarily a prescription drug, it is sometimes used in high doses for recreational opioid effects. It's been a half hour. 3x regular dose) Tianeptine Sulfate would get you the same peak blood plasma concentration as the Sodium version (~430 ng/ml), however, it would last much longer, with significant levels still in the blood 12 hours later (~204ng/ml). I've heard that tianeptine can cause opioid like effects in higher doses whats a common dose for recreational purposes? like eg how much tianeptine is comparable to 50 mg morphine? I found no dosing information online. The other took 2800 mg in four doses throughout the day. If after 90 min you dont get relief then reassess. Tianeptine is an unapproved drug in the U. Don't take 40mg of tianeptine sodium, that's too much, though you can go up to 20-25mg. , then your conversion for Tianeptine Sulfate is ~40mg q. Structurally, it is classified as a tricyclic antidepressant (TCA), however, it possesses different pharmacological properties than typical tricyclic antidepressants 1 . But, I took 6 TD red on top of the agmatine and sulfate (again, I can't ever get high while I'm still riding the sulfate) and the TD red got me high as fuck on top of the sulfate. We never re-dose or use tia two days in a row or more than twice a week. Back To Resources Drug Specific Lindsey Morano August 10, 2021 english , text , tianeptine , tia , zaza , tiana , dose , withdrawal , side , route , administration In summary, tianeptine is a well-described antidepressant with effective actions against stress-induced sequelae of the nervous system. Both subjects reported that their time between tianeptine sulfate doses (varying 100 -200 mg) immediately lengthened by 15-30%, as the agmatine was clearly increasing the systemic duration and efficacy of Lastly, I believe the equivalent dose of sulfate to sodium is 45mg or something. Desired effect wears off too quickly; short-acting; need to dose frequently. 5mg doses. Does this mean Tianeptine ethyl ester is a prodrug for Tianeptine sulfate? Is Tianeptine ethyl ester sulfate the same as Ethyl Tianeptine i? So I’m conclusion: Tianeptine is fine in normal doses daily (12. 5-25mg dosages, not 100-150mg dosages. The prescription drug is produced as tianeptine sodium. Kratom is about 1 billion times easier to manage and get off of in my opinion. This morning I increased the dose to 20mg in the empty capsule, but still May 9, 2025 · "Case reports in the medical literature describe U. 5mg x3 sodium = 40mg sulfate. 5 mg, usually 3x a day. Tianeptine is usually packaged as a sodium salt but can also be found as tianeptine sulfate, a slower-releasing formulation patented by Janssen in 2012. Therapeutic Category: Antidepressant, tricyclic CAS: 0066981-73-5 Chemical Formula: C21H25ClN2O4S There is no real recommended dose, as we don't have accurate human pharmacodynamic data. Without tolerance, usually 50mg-100mg is required to really feel its opiate effects. When tapering plan for a proper amount at bedtime. GameStop Moderna Pfizer Johnson & Johnson AstraZeneca Walgreens Best Buy Novavax SpaceX Tesla. I've seen it said a few times around the interwebs, that approx. May 14, 2025 · The drug is typically available at gas stations, convenience stores, vape shops and online retailers, according to the FDA. I'd say in general, it takes about 20-40 minutes to kick in. When switching to sulfate keep in mind that full effects of a dose do not reach peak for 1. 5 hrs of high. Business, Economics, and Finance. See full list on azbigmedia. La tianeptine n’est pas recommandée chez les enfants et les adolescents de moins de 18 ans. The suggested prescription antidepressant dosage of sodium is 12. Several hours later I mixed it in some water to see if that would produce results, still nothing. , it can be bought online and at small stores. 5 mg) results in ~ 1 μM maximal concentration of the drug in the plasma What does this mean? A 12. Dose 1: 230mg upon waking (don't do unless your tolerance is like mine). This is the subreddit for users trying to quit Tianeptine. When taking tianeptine sulfate, I dose 25mg of powder sublingually. , tianeptine is not approved for any medical use. At other times we enjoy about 6 hours of bliss with 100 mg of sulfate. I'm actually starting to like the feeling more than sodium. r/Tianeptine A chip A close button. The setting made this dose unenjoyable. d. You will be on enough to feel ok but no high. Or check it out in the app stores Oct 20, 2023 · Tianeptine is an over the counter antidepressant that mimics opiates in some ways and can be highly addictive. sulfate, so does that equate to 300-400mg of t. Increased anxiety. I don't find any benefits from splitting the doses. The sulfate is much forgiving in his regard, and single doses of 50-60mg, spread out, shouldn’t lead to rebound anxiety or adddoction/tolerance. It increases serotonin (5-hydroxytryptamine; 5-HT) uptake in the br Posted by u/rileycreek652 - 1 vote and 9 comments Has anyone successfully tapered off Tianeptine with Tianeptine Sulfate ? The question I have is I have aquired meds over the last few weeks and have Gabapentin 800mg (20+) I have Subutex 4mg (3 pills) I have Xanax 1mg (25 or so) I also have lots of clonidine and Lucemyra which is a “new” drug used for opiate withdrawal similar to clonidine. Considering the high co-prevalance of anxiety with depression, tianeptine could prove to be the superior drug for these patients. 5mg x 3 = 38mg would be, and even smaller if you took the 12. I measure out my dose and just lick it up so it took about 20-30 minutes to enter my bloodstream. Si vous avez pris plus de TIANEPTINE BIOGARAN 12,5 mg, comprimé enrobé que vous n’auriez dû Feb 1, 2024 · Reddit has a "quitting tianeptine" forum with more than 5,200 members. I am getting up in the morning and enjoying my photography hobby, going for runs, and have much more professional motivation and less desire to waste time/play video games all day. Overdose. I took around 200mg tramadol 4 times per day and reduced my Tianeptine dose from ~700mg to ~300mg over the course of a month, still taking it about 10-12 times a day. I was feeling fine. But on this sub, people don’t use it responsibly and are having an awfully difficult time coming off it. A single 40mg dose of sulfate is equivalent to (3) 12. However, it can also be found on the Internet as tianeptine sulfate sold as a nootropric. If you want to talk about using it responsibly then head over to the tianeptine sub and speak there. 5gpd Buy high quality Tianeptine online from a trusted US Vendor. Control Status: Tianeptine is not controlled under the Controlled Tianpetine probably has similar rates with certain side-effects in common SSRIs such as dry mouth and nausea. 1630 25mg sulphate On Wednesday, Thursday and Friday I found the effects very stimulating - almost like low dose MDMA. " It's pretty common knowledge by now, in r/nootropics, that if you're taking Tianeptine Sodium 12. So, a prescription tianeptine (sodium) user would start 12. Tianeptine is fantastic, when used therapeutically. On almost every day, I take it again just before bed. I split it into 5 equal piles (each pile = 1 gram). 5-25 mg at once, 3x a day) (low withdrawal risk) . All in all I’m a big fan of this form. Seems the dose is equal to 60 mg Tianeptine Sulfate as well so that is a plus. Misuse of tianeptine sodium has been documented, but there’s little scientific evidence of tianeptine sulfate use. along with other adverse side effects like lethargy, elevated blood pressure and To give you an idea of it’s strength, 200 milligrams of Tianeptine Sulfate equals 100 milligrams of Tianeptine Sodium. It is classified as an atypical tricyclic antidepressant and has shown potential benefits in addressing anxiety and irritable bowel disease. If you find that you are able to use tianeptine without too much issue, try to follow to the best of your ability the protocol doctors use in countries where the drug is prescribed and don't exceed those doses. The U. Lowest prices! Purchase tianeptine sodium, sulfate, free acid and solution Buy Tianeptine. All at once. Basically double reccomended dose, and had intended to max out at 40mgx3 or 60mgx2= 120mg a day to match what I mistakenly thought was the therapeutic dose. Posted by u/ifIwerestewie - 1 vote and 4 comments We do NOT promote drug use; - Accept, for better and or worse, that licit & illicit drug use is part of our world and choose to work to minimize its harmful effects rather than simply ignore or condemn them; - Utilize evidence-based, feasible, and cost-effective practices to prevent and reduce harm; - Call for the non-judgmental, non-coercive provision of services and resources to people who I received 2g tianeptine sulfate powder today from Ceretropic. When switching try a best guess amount of sulfate and WAIT. 12. Some people share stories of trying to stop using tianeptine while others post about using tianeptine to lessen dependency on It turns to goo when exposed to air. Never have an urge to redose or use more often. Went six hours from last Tia dose to sub and took care of most of the withdrawal symptoms. 3 to 250 times (50 mg to 10,000 mg) the daily tianeptine dose typically recommended in Tianeptine is a very mild opioid, as well as a tricyclic antidepressant so you have t take large doses to feel the opiate effect, and by that time you get bad side effects from the tricyclic part of the drug. 5mg dose. If you were to dose 7mg of sulphate every 5 hours 3 times a day, when you wake up the second day your blood tianeptine would be around 3mg, rising to 10mg after your first dose, lowering to 5mg before your second dose, rising to 12mg after and then 6mg before your third dose. I'm going to be trying it for pain relief as soon as I figure out a reputable place to get the sulphate kind w/the While this offers advantages for tianeptine over the tricyclic antidepressant agents in terms of dose titration, treatment changes and potential drug interactions, its rapid elimination makes adherence to dosage schedules more important. I’ve just done that, myself at around that amount. The last few times, I just stopped taking it one day and was May 26, 2014 · Yeah i ended up on reddit looking around, Seems the Sulfate absorbs slower into the body and requires a higher dose, vs the sodium which absorbs faster and the effects seem to be stronger. I could feel the effects within 40-45 mins after ingestion. 5 mgs three times a day. consumers ingesting daily doses on the order of 1. The feeling of a large sulfate does is comparable to a low dose of methadone. Kratom has a ceiling effect that really does not allow one to get super duper high, tianeptine allows one to get super, duper, duper high, and it builds tolerance and physical withdrawal effects much, much faster and these withdrawals are much, much, much more severe than any Tianeptine Sulfate is complicated, it's significantly affected by food intake unlike Tianeptine Sodium. It seems to have a longer duration all around. 5gpd to 1. The Sodium hits a lot quicker so it's definitely more useful at times of severe anxiety when you need a quick fix. The therapeutic dosage for sodium is 12. Much of the recent literature regarding tianeptine comes from case reports and review articles. Been on and off both several times. either people take crazily high amounts or therapeutic amounts. Overdosing tianeptine is stupid. The quoted number of 40 mg was an original guideline calculated by MYASD based on molecular weight and tianeptine sodium dosage, but 25 mg comes from user experiences. Several available studies have been conducted to determine the role of tianeptine as a drug of misuse. Many people use tianeptine to treat their ailments, believing it is safe Tianeptine Sulfate, though pricier, offers a smoother tapering process due to its extended effects. That isn’t a low dose of sulfate, but I would say you should be okay with that overall and could easily taper over a week or two if needed. Tianeptine sulfate not as effective as tianeptine sodium. On some days, I will take a dose around midday. If you or someone you know is struggling or in crisis, help is available. Usually people start at 25mg, though. Severe vein damage from injecting. Personally, I've had positive experiences with tianeptine from rcd. Dependence Look for “tianeptine,” “tianeptine sodium” or “tianeptine sulfate” listed in the ingredients or supplement Just to be clear, this is tianeptine sulfate, not tianeptine sodium, that's why it's 40mg instead of 12. CDC used NPDS data to review all tianeptine exposure telephone calls reported by U. Downsides unspecified. Tianeptine I then started to research things that are safe to take with these two that can help more with athletic performance and after some research, I decided to add Phenylpiracetam (60mg) to the stack while lowering tianeptine sulfate dose to 60mg as well They actually physically audit the facilities in china that produce their products, and test every batch both in-house and with 3rd party testing facilities (and they've recently posted these test results on Reddit to assuage any concerns. The short half life sucks, but oh well, it's not hard to dose 3x a day. I've read that sodium tianeptine takes about an hr to work & only last around 2-3 hrs total. Wednesday / Thursday / Friday: 1130 25mg sulphate. At that dose (or any starting dose), the body will adapt and quickly achieve homeostasis which naturally leads to upping the dose in order for it to remain effective. However, it is important to note that tianeptine is not approved for any use by the United States Federal Drug Administration (FDA . sulfate? however some sources claim that ~100mg sulfate is enough. Hello there! I recently found out about a drug called Tianeptine, which acts as an antidepressant through serotonin reuptake enhancement. Tianeptine is used as a prescription drug in some European, Asian, and Latin American countries, but it is not approved as a drug in the United States. Confusion. 5-50 mg two times each day to get the same amount of the tianeptine molecule as the standard dosing for tianeptine sodium? Tianeptine is not as bad, but is also only meant to be taken at 12. I learned after 12. I picked up some Tianeptine sulfate from nootropics depot. I then wanted to know what happened if i upped the dose and did like 100 mgs at once Didn't feel much. The difference between the two forms of Tianeptine you mentioned are efficacy and half life. Then 3 days cut that amount , etc etc. Poison control center cases involving tianeptine exposure have increased nationwide, from 11 total cases between The sulfate does seem to last longer and have a gradual come up and down, I would dose 20mg 2x a day (sometimes 40mg 1x a day). 5mg - 25mg (ie 1-2 Stablon tablets) PRN 0-10 x a week. I usually dose 20-25mg in the morning, and 30mg before lunch. I'd say it just depends on your willpower and self-discipline. As w/anything start w/the lowest possible dose. Looking for a opiate-like experience with a great deal of euphoria. Be aware that Sulfate absorbs much slower than Sodium. 5 mg three times a day, then tianeptine sulfate should be dosed around 37. I use it about once a week for pain-relief, mood enhancement, and stamina. I was steady at roughly this dose for the last 8 months, then started tapering in earnest a month ago from that point. Tianeptine sulfate; Tianeptine sodium So you have people buying Tianeptine and abusing it for an opiate high (which is hilarious because it's not the point of the drug, and they're spending unbelievable amounts of money for a drug with a very weak opioid properties), while not understanding that it works in the background and is not necessarily supposed to provide immediate relief. Don't do that. Jul 14, 2024 · For decades, tianeptine was used to treat depression, even though no one knew how it worked. See for example this reddit thread and this article. It has been the best month in a long long time. I have been taking 40mg 2x a day with good effects. I sometimes take more than the suggested dosage, but have no side effects. Moderate discomfort but manageable. I've noticed that eating a small to medium sized meal about 4 hours after a sulfate dose brings out the feeling quite a bit. I've read constantly that 100mg is a high recreational dose. 5mg 3 times daily. it lasts yeah about 1. If I’m using Tianeptine at therapeutic doses, how bad will the cross tolerance be? Will I really just have to commit to 1 of the 2 drugs? Also, does Tianeptine satisfy kratom cravings and stop withdrawals? 40mg is notably over my dose, and I don't use capsules. Mar 29, 2024 · Tianeptine is a medicine available for use in some European, Asian and South American countries to treat anxiety, depression and irritable bowel syndrome. 5mg sodium. It is as effective as SSRIs in treating depression, produces fewer adverse side effects and reduces anxious symptoms associated with depression without the need for concomitant anxiolytic therapy [5,16,19,61,188]. so did another 50 like 2 hours later The average Cmax value for Stablon in the table is 464, and the three Cmax values for the CR tianeptine sulfate tablets (multiplied by 1. I feel bad for what I read on here as from an outsider’s perspective, we see US nihilism. bio and found their products effective for tapering purposes. 25, 138. If you take tianeptine, I'd recommend the sulfate form. " Tianeptine poses a "dangerous and growing health trend Posted by u/Opposite-Departure-2 - 3 votes and 7 comments Jul 15, 2023 · Tianeptine is an antidepressant drug approved for the treatment of major depressive disorder in countries other than the US. Tapering back down was easy though. [ 67 ] Feb 2, 2024 · Side effects of tianeptine use include: Agitation. Nothing happened to calm me down, and I was confused about how calm I suddenly became then I realized it was probably the tianeptine, lol. org. --- Generic Name: Tianeptine sulfate Brand Names: Coaxil, Neluptin, Stablon, Salymbra among others. The other thing is, are you depressed? I don't notice much from tianeptine when I don't feel sad/dysphoric. recently received 2 grams of tianeptine sulfate. So dont keep dosing up thinking your not getting an equivalent amount. I was hesitant to dose Tianeptine due to cost (was broke as shit student for 7 years) but somehow found a way to always have weed ;) Well guess what? …she has an established drug addiction to kratom. 5mg of tianeptine sulfate and i will see how i feel. I ingested this and felt absolutely nothing. 25 to account for molar mass difference to represent a sulfate dose of 15mg) are 186. Maybe even the opposite: enhance the experience and reverse loss of libido and delayed ejaculation caused by other anti-depressants. poison control centers during 2000–2017. So taking 50 BID of the sulfate is higher, but not crazy. Tianeptine is a drug used primarily in the treatment of major depressive disorder and has been studied in the treatment of irritable bowel syndrome (IBS) 3. Unlike other antidepressant agents, tianeptine stimulates the uptake of serotonin (5-hydroxytryptamine; 5-HT) in rat brain synaptosomes and rat and human platelets, increas … I have been experimenting with Tianeptine over the past week and have noticed the effects have not been consistent at all. I went to see a therapist about the death of my friend. We would like to show you a description here but the site won’t allow us. The sulphate tianeptine is supposed to be longer lasting. Crypto Aug 10, 2021 · This guide talks about what is tianeptine and how it works including effects, side effects, dose, route of administration, withdrawal, and overdose prevention. I tried the sulfate for a couple of weeks and didn't notice much, the sodium maybe provided some small lift after trying it for a month but I was getting more benefit from my MAOI and dropped it. I put it in an empty capsule. Went you get down to 50 mg I would just jump off. It does NOT dissolve in water. 3 to 250 times (50 mg to 10,000 mg) the daily tianeptine dose typically recommended in Jan 12, 2024 · But the potential for abuse of tianeptine and the toxicity it causes outweigh all benefits. i. Negative affect at high doses. Food and Drug How much tianeptine sulfate should I take? No research has been conducted to determine a safe dose of tianeptine sulfate powder. There is an intoxication, but it's If used at 12. but man that 45 minute section where you go from barely feeling it to peak is amazing. Update: 20-30mg seems like an appropriate dose once a day. No real high noticed, but I have no cravings either. 5mg dosages of sodium. Like the other poster said, if I take enough it's like I could not be sad or get upset. I first started with 30 mgs, and it was nice, had a solid mood boost for like 5 hours and had no noticeable come down. If you’re going to abuse tianeptine in high doses, occasional (one dose every several weeks or months) is fine (low withdrawal risk) The whole point of using the sulfate is to get the benefits of tianeptine without the short half life of and high peak plasma levels of the sodium. 5mg sodium = 40mg sulfate. So a pack of 30 pills would last 10 days. At this dose my cognitive function did not feel impaired nor did I experience any negative side effects. Calls for drug information or identification were excluded. I also have a jar of Tianeptine sulfate (which produces similar nootrotpic\mood boosting effects as the Tianeptine sodium) does anyone have any experience with Tianeptine sulfate at recreational dodges? In order to further explore this drug I definitely want to try it at a higher 'recreational' doses. 40 mg of Tianeptine Sodium (short lasting) or 90 mg of Tianeptine Sulfate (long lasting) and I'm good to go. At higher doses, 50-60 mg, there is noticeable sedation which would definitely impair my ability to drive. The only interesting thing I notice from this form but not sooo much in regular sulfate is a bit more of a stimulant effect, which I am Some people have come to associate that 'side effects = something must be working', but agmatine has nearly no side effects, at least for me. If affordability allows, tianeptine Sulfate could be a worthwhile option. We are a supportive community who wants to help anyone who needs help. However, so much about the drug is Today I had already taken my agmatine and my sulfate dose for the morning. The guy who runs nootropicsdepot did the math and apparently 45mg Sulfate =~ 37. 15 votes, 60 comments. The substance also acts on opioid receptors and, in large enough quantities, can produce some nice euphoria. true. On most days, I take another dose in the early evening. Each 1 gram pile is 1000mg. I believe most literature describes up to 100mg/day as still being in the therapeutic range In the U. Tianeptine (trade names Stablon and Coaxil) is an atypical antidepressant. Looking at the powder, I am realizing what a tiny amount a daily dose of approximately 12. What are the side effects of tianeptine? idk the dose i take the mystery dose gas station pills lol. is facing a spike in abuse of "gas station heroin. Get app Get the Get the Reddit app Scan this QR code to download the app now. For me, it seems to have a very narrow range where it's effective without being too much, and when you factor in the variability it becomes nearly impossible to be consistent with it during the day. 5 3X a day, and might go up to 25mg 3X, you need to be taking at least 75mg sulfate to match that, (or at least I did, lol). 5mg over the usual sodium dosing in a day. We use both tianeptine sodium and sulfate. I also suspect people are dosing improperly, taking large doses 1-2x per day rather than following the model of human studies that use lower doses (<500mg) 6x a day, roughly every 2 hours. Day 1 - last dose at 11:30am May 9, 2025 · Case reports in the medical literature describe U. Stage 2 - 3. sodium is ~100mg, and is between 3-4 times more potent than t. Mode d’administration. Mar 19, 2024 · The drug is referred to as “gas station heroin” because it produces opioid-like side effects and is available at many gas stations and smoke shops. 5mg t. Nothing snuck up on you, you were well aware of the normal dosage at the start but increased it to a gram per day, 25x the normal daily dosage, ignoring both the dosage guidelines and all available anecdotal and clinical information about it. I had given up on antidepressants but decided to give it a try, I felt a difference within minutes. This is in addition to tianeptine sulfate I have taken for years. In other countries, including the U. 5mg It's not the same compound. I take Vyvanse daily, and when my motivation started declining, my psychiatrist's solution was a 15mg Adderall booster for the afternoon. If possible, it was taken with, or shortly after the tianeptine sulfate dose. BTW I am well aware that Tianeptine acts more like an opioid than an antidepressant, nevertheless the fact remains that it IS an atypical tricyclic antidepressant. Sulfate gives me a nice subtle high that lasts all day. Most frequent side-effects of tianeptine are insomnia, dry mouth and constipation. Sulfate is somewhere around 40% less effective as sodium so you need a larger dose, however, it has a longer half life so you do not need as many doses. 5-25mg 3x per day. Would it then follow that: Tianeptine free acid would have a little bit more of a peak, that would then taper off very slowly; Tianeptine sulfate would have a slow and steady effect all the way through; and both versions make it difficult to achieve a level of absorption that could produce a Tianeptine "high" or overdose. But the article follows up with information about the anxiolytic properties of the drug compared to SSRIs. NFLIS-Drug received over 190 reports of tianeptine since its first report in 2017. 5mg of Sodium = 40mg of Sulfate. So im going to order 500mg of the sodium and see how it compares to tramadol , since i do use trams for anti-depressant effects from time to time perhaps Relax like i said to the other redditor i will try a light dosage of 12. I went from taking 8-12 of the enhanced extracts capsules a day down to 3 total the last twenty four hours and now a half of a 4mg1mg suboxone strip and have no more opiate like withdrawals. 5 and then 50mg. I started out with the recommended 12. I have a milligram scale ordered that should arrive this week. I was taking tianeptine sulfate during the 3 days leading up to withdrawal. Since Tianeptine Sodium is dosed at 12. My sulfate just arrived in the mail, and Im a little concern that the cross tolerance will ruin Kratom for me. Posted by u/bconaughty - 1 vote and 15 comments May 9, 2025 · This article discusses suicidal ideation. Start on the lower end of the spectrum and adjust from there. Aug 3, 2019 · Among 83 tianeptine exposures with noted coexposures, the most commonly reported coexposures were to phenibut, ethanol, benzodiazepines, and opioids. Anyways, I find 80mg a day works for me. I’d wanted to quit for months, and this forced me. Sometimes you need a short, strong dose of pain-free energy which, in our case, calls for 40 mg of sodium. I personally stayed at that dose for 3 weeks before going up to 37. Learn more about TIANEPTINE uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain TIANEPTINE. In other words, if the standard dose of tianeptine sodium is 12. Aug 31, 2019 · La tianeptine est contre-indiquée chez l'enfant et l’adolescent de moins de 15 ans. but what is a common recreational dose especially if your tolerance to opioids is n It seems like the consensus is around 25 mg per day, but reported use varies mostly between 20 and 40. And you’re on a sub full of people who took way more than the recommended dose. as one single dose for the whole day) Having collectively established this general consensus, I think we should start reporting what dosages actually work for us. 75 and 125. Hope this helps. Maybe it would be slightly prolonged, but it wouldn't just add on top of the initial dose. 5mg dose (the recommended dose) will result an in vivo concentration sufficient for the activation of MOR (EC50 ~ 0. then gotta wait a good 6 hrs from last dose to be able to get high again from what I gather, a recreational dose for t. It's been life-changing to shed my fear of sleep. YMMV of course, so do your research. Food and Drug Administration is warning the public about a drug rising in popularity, commonly referred to as "gas station heroin. Some of these poisonings occurred the first time people ingested the substance. So, I bought 2 gs of tianeptine sulfate powder from noot depot. This last dosing period is the critical one for me. Tianeptine differs from most antidepressants in that it is not primarily metabolised by the hepatic I just received my first order of 5 grams of sulfate in the mail. I will not be trying out any new medicines to be honest i have tried over 30 different supplements and it got me no where but trying to find a cure for my fuzzy head and daily tension headaches. I took my first dose of tianeptine yesterday (also sulfate from ceretropics). In that condition, even 1g of sodium doesn't ever get me high. " I don't do a lot of reviews so ask away if I overlooked it. I mistakenly thought 12. I do notice a slight but positive increase in mood. Although tianeptine is not approved in the U. I would suggest taking just one 25mg dose for at least a week, preferably 2 weeks, before determining if you want to try a second 25 mg dose (or like I did at first, half a capsule for a second dose). So if I split that pile into 10 equal piles, I will have roughly 100mg. 2–1 μM) but not DOR. The only viable therapeutic form is getting a legit prescription, where if you try to go for recreational dosages, you run out a month-worth supply in a few days. 5mg three times daily. Call or text 988 or chat at 988lifeline. So is there a verdict on the sodium vs sulfate differences? I've only used tianeptine sodium (from ceretropic). e. I'd describe it as "nice. Please let me know what you guys think: Tianeptine is an antidepressant agent with a novel neurochemical profile. Analysis of tianeptine use in the United States is limited, with most publications originating from other countries . Anhedonia. I just ordered a pretty large bag of powder to save some $ wondering how to physically dose this baby got some coming in by hopefully this weekend both sulphate and sodium. Most will take it 3x a day. I haven’t had trouble getting off 100mg/day of sulfate several times now over the years. But it turns out it's a type of opioid, and the U. To prepare, I purchased green bali kratom powder, 3 packages of immodium tabs, and cold & flu medicine all on a friend’s recommendation. The pills are expensive when you consider the recommended dose is 12. So 50mg Sulfate a day isn't too much I used to take tianeptine sulfate @ 100mg a day 1st thing in the morning on empty stomach. Recreational use Please do not inject tianeptine! The recreational dose for beginners starts at 100mg, some reddit users have admit to go up to 10-20g a day! Stay away if you don't want to become addicted. I have the same issues as you. Only non peer reviewed research that exists is on tianeptine sulfate with a special slow release polymer. I didn't feel my typical high or notice any difference with that first specific dose so later I tried again and still didn't feel as if the agmatine was doing anything. It has a unique and poorly-understood mechanism of action consisting of modulation of the brain's monoaminergic and glutamatergic systems. So far I’m trying 20mg to see how it goes and will compare it to 25mg sulfate. . In humans, a single dose of tianeptine (12. Works wonders for focusing, but not on motivation. Am I setting myself up for disaster? Dosage: Sodium=15-25mgx2 OR Sulfate=30-50mgx1, I set exact dosage according to my feelings at that moment. This compares to 151 cases in 2020, and only 4 in 2013. While still feeling the effects of the first dose, I redosed 280mg. Tianeptine sodium was also a dosage dependent mood booster, but it didn't cure nightmares. While Tianeptine sulfate works very well at eliminating anxiety and depression, I worry about the long term consequences and plan to stop its use. I worked myself up to 700mg for a while. Tianeptine sodium is shorter lasting than tianeptine sulfate. I don't know enough about reagent testing to say for sure, but I've never gotten a bad batch of tianeptine sodium or sulfate in my 2 years of use. (i. Voie orale. The third dose depends on if I need to go out, etc - sometimes I don't take a third dose of sulfate and just take 10-20mg tianeptine sodium because it doesn't last as long (sulfate can mess with my sleep). Going to chime in here and say that tianeptine is worth trying, if you want to. Tianeptine Sulfate Experience Hello friends, I've recently had the pleasure of experiencing the effects of tianeptine sulfate. , reports of severe side effects involving tianeptine are increasing. I know that this dose is currently 12. In your example, I would feel the initial 100mg, wait say 30 mins, then take the other 100mg And I wouldn't feel anything above a standard 100mg dose feeling. Has anyone else experiences Based on the graph of effects, it looks like one daily dose of 41mg (3. 5mg, 3x a day as well as tianeptine sulfate 25mg/50mg once a day. All the newspaper articles we read are about a dying countr Maybe something like therapy, a healthier diet, or trying to do more exercise can help. I used to take it briefly and a dose of 30 - 40 mg of the sulfate lasted ~8 or so hours. 200mg sulfate works well for me too. Many here are currently addicted, as well as former users who remain to offer advice and encouragement from the other side. I am hoping someone can help me understand why. openresty May 9, 2025 · The U. Although this drug is cheap, easy to obtain, and mind-altering, it can also be extremely dangerous and addictive. The recommended dosage of sodium is 12. com Currently using tianeptine to substitute for suboxone, I'm on day 5 without any, and its working really well. 3 to 250 times (50 mg to 10,000 mg) the daily tianeptine dose typically recommended in Laboratory Information System (NFLIS) Drug database collects scientifically verified data on drug items and cases submitted to and analyzed by federal, state, and local forensic drug laboratories. Longer come up, peak, residual effects. Although other countries have approved tianeptine to treat depression and anxiety, some have restricted how tianeptine is prescribed or dispensed, or May 8, 2025 · Case reports in the medical literature describe U. This article explores what Zaza is and why it is so dangerous. In 2023, 391 cases of tianeptine poisoning were reported in the United States. I tried tianeptine sodium at 12. Prefer tramadol or DHC very low dose. Tianeptine--an instance of drug-induced hepatotoxicity I took sodium for a year or so at 25mg, then switched to sulfate, and what you have to realize is that sulfate lasts longer but is a little weaker. So figure 1:3(ish). When it goes out, I just buy another of the same scale - they last a while. I took 50mg of tianeptine sulfate this morning, feeling pretty good right but now I am just left wondering how many times I can take this stuff on a… Dec 1, 2023 · Tianeptine attaches to the same receptors in the brain as an opioid, typically producing a similar effect, which is part of what makes the drug so appealing. I recently tried a high dose of agmatine with about 1-200mg less tianeptine than normal at the start of my day to see if I can attempt to lower my daily tianeptine dosage. How much would be a good dosage?… And usually whatever your current dosage is, you can cut out 2/3 of it right away. But I didn't experience anything. Further research is needed to Jan 24, 2024 · The US Food and Drug Administration is warning consumers not to purchase or use any tianeptine products, saying it continues to receive reports of severe adverse events, including death, linked to Dec 30, 2012 · It doesn't cause sexual problems which is very frequent side-effect of SSRIs/SNRIs. Depressive symptoms. As such, tianeptine sulfate dosing should follow the same 12. It's not when abused. I figured that taking 2x 25mg sulfate capsules once daily is what is going to provide the desired therapeutic effect. I had a friend from South Africa who’d use Tianeptine Sulfate to get high as that’s all his South African domestic vendor sold Tianeptine-wise and he’d typically take 500 milligrams of Tianeptine Sulfate. 5mg/3 Stablon doses, it might be a useful and effective drug, but I can't visualize this happening. Tianeptine is a novel antidepressant agent, both structurally (modified tricyclic) and in terms of its pharmacodynamic profile. Review the use of tianeptine sulfate without prescription. Tianeptine sulfate is a dosage-dependent mood booster for me if taken during the day, and the cure for a lifetime of nightmares if taken just before bed. Tianeptine is also much more addictive than Kratom (though, like Kratom, this only happens if you continually increase your dose to chase the high). 5 hours. Objectives. Mar 17, 2017 · 303 See Other. I read that: “Tianeptine ethyl ester sulfate is a stable salt of an ester compound which is a precursor to Tianeptine…”, and: “Tianeptine ethyl ester” is also a synthetic intermediate fo Tianeptine. 75mg/day isn’t a recreational dose, especially sulfate. I took tianeptine sulfate during a panic attack once and then I suddenly started calming down very quickly about 15-20 minutes after taking it. [66] In 2022 Tonix Pharmaceuticals received permission from the US FDA to conduct phase II clinical trials on tianeptine hemioxalate extended-release tablets designed for once-daily use. At the recommended dosage of around 10-15 mg I noticed immediate antidepressant effects. No exhaustion, no diarrhea, no bone aches, no RLS, it's proving wonderful. but yeah i take it once, redosing doesn’t work at all. kwvjk cag vcs tpicqza xlaadyx pbhf nlusbx cxacb aqicxo jmvme